This is the Germline Mutations data set of the IARC TP53 Mutation Database (Rel. 12)
The dataset of germline mutations is a module of the IARC TP53 Database. It contains information on families fulfilling the definition of Li-Fraumeni and Li-Fraumeni-related syndromes and on individuals carrying a germline mutation in the TP53 gene. Data are extracted from peer-reviewed articles. Unpublished data from Eeles et al are also included. Criteria for inclusion are the following: a) individuals carrying a sequenced TP53 germline mutation, affected or not by a cancer, b) individuals affected by a cancer and belonging to a family defined as LFS or LFL, presenting or not a germline mutation (TP53 or other).
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