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For information, get in touch with: Dott.ssa Paola Visconti
Email: paola.visconti@hsanmartino.it
  P. Romano, A. Manniello et al. Nucl Acids Res 2009 37:D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105


IM-9 (human, lymphoblastoid B cell, multiple myeloma)


SPECIES: human
TISSUE/ORGAN: lymphoblastoid B cell
TUMOR: multiple myeloma

DSMZ catalog code: ACC 117
Morphology: lymphoblastoid, single or clumped cells in suspension
Description: human B-lymphoblastoid cells (from patient with multiple myeloma) established from the bone marrow of a woman with multiple myeloma in 1967; cells were described to synthesize IgG and to have receptors for insulin and calcitonin; cells express bcl-2 mRNA; cells appear to be rather 'EBV+ B-lymphoblastoid cells' than myeloma-derived cells (see also Pellat-Deceunynk et al., Blood 86: 4001-4002, 1995) confirmed as human with IEF of AST, MDH, NP, PEP B
Viruses: ELISA: reverse transcriptase negative; PCR: EBV+, HBV-, HCV-, HHV-8-, HIV-, HTLV-I/II-
Depositor: obtained from ATCC (CCL 159), Rockville, Maryland, USA
General Restrictions

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: CCL 159, ICLC: HTL99009, IZSBS: BS TCL 98

Bibliographic references:


IM-9 (human, Caucasian, bone marrow, multiple myeloma)

IZSBS catalog code: BS TCL 98
Continuous culture, grown as suspension
Lymphoblast-like morphology
SPECIES: human, Caucasian (female) Karyology: 2n = 46 in 50 cells
TISSUE/ORGAN: bone marrow
TUMOR: multiple myeloma
DEPOSITOR: obtained from ATCC
PROPERTIES: This cell line has been used extensively in biosynthetic and surface marker studies presenting receptor sites for human growth hormone, insulin, calcitonin; Ig prod.

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: CCL-159, DSMZ: ACC 117, ICLC: HTL99009

Bibliographic references:


IM-9 (human, Caucasian, bone marrow, multiple myeloma)

Continuous culture, grown as suspension
lymphoblast-like morphology
SPECIES: human, Caucasian (female)
TISSUE/ORGAN: bone marrow
TUMOR: multiple myeloma
PROPERTIES: IgG kappa prod.; growth hormone receptor, human; insulin receptor; calcitonin receptor; tumorigenicity; immunofluorescence; hormone studies; bcl-2 mRNA expression

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: CCL 159, DSMZ: ACC 117, ICLC: HTL99009, IZSBS: BS TCL 98

Bibliographic references:



For information, get in touch with:
IRCCS Ospedale Policlinico San Martino
Largo Rosanna Benzi, 10 - I-16132 Genova - Italy
Dott.ssa Paola Visconti
Email: paola.visconti@hsanmartino.it

If you want to cite CLDB and HyperCLDB, please use the following reference:

P. Romano, A. Manniello, O. Aresu, M. Armento, M. Cesaro, B. Parodi.
Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines.
Nucleic Acids Research 2009 37(Database issue):D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105