THP-1's homonymous lines

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For information, get in touch with: Dott.ssa Paola Visconti
Email: paola.visconti@hsanmartino.it

P. Romano, A. Manniello et al. Nucl Acids Res 2009 37:D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105

THP-1 (human, peripheral blood, leukemia, acute monocytic)

ICLC catalog code: HTL97014
Continuous culture, grown as suspension
large, round, single cells morphology
SPECIES: human (male, 1 years old)
TISSUE/ORGAN: peripheral blood
TUMOR: leukemia, acute monocytic
DEPOSITOR: Dr A. Rubartelli, Clinical Pathology Dept, IST, Genoa, Italy.
Cell line available for distribution. For non-commercial investigative use only
PROPERTIES: differentiation; lysozyme synthesis; phagocytosis; Fc receptor; IL-1 production; C3b receptor. HLA: A2, A9; B5; DRw1, DRw2

Available in the following LABORATORY:

IRCCS Ospedale Policlinico San Martino (ICLC, Genova)
RPMI 1640 + 10% FBS + 2mM L-Glutamine; Freezing medium: Culture medium + 50% FBS + 10% DMSO; Maintain cultures between 2-9x105 cells/ml. 37C, 5% CO2 , mycoplasma negative, HOECHST and PCR
Validated by: identification confirmed by Short Tandem Repeat (STR) profile (Amelogenin: X,Y; vWA: 16; FGA: 24,25; TH01: 8,9.3; D18S51: 13,14; D21S11: 30,31.2; D8S1179: 10,14) * isoenzymes (confirmed as human with G6PD, NP)

Availability in cell line catalogues: DSMZ: ACC 16

Bibliographic references:

Cancer Res 1982;42:1530 - PMID: 6949641
Int J Cancer 1980;26:171-176 - PMID: 6970727
J Immunol 1983;131:1882 - PMID: 6619543

THP-1 (human, peripheral blood, leukemia, acute monocytic)

Continuous culture, grown as suspension
large, round, single cells morphology
SPECIES: human (male, 1 years old)
TISSUE/ORGAN: peripheral blood
TUMOR: leukemia, acute monocytic
Susceptibility to viruses: HIV-1
PROPERTIES: differentiation; lysozyme synthesis; phagocytosis; Fc receptor; IL-1 prod.; C3b receptor

Available in the following LABORATORY:

Russian Academy of Sciences (SPBIC, St. Petersburg)
mycoplasma negative
The cell line can differentiate into macrophage-like cells.

Availability in cell line catalogues: ATCC: TIB 202, DSMZ: ACC 16, ICLC: HTL97014

Bibliographic references:

Cancer Res 1982;42:1530 - PMID: 6949641
Int J Cancer 1980;26:171-176 - PMID: 6970727
J Immunol 1983;131:1882 - PMID: 6619543

For information, get in touch with:
IRCCS Ospedale Policlinico San Martino
Largo Rosanna Benzi, 10 - I-16132 Genova - Italy
Dott.ssa Paola Visconti
Email: paola.visconti@hsanmartino.it

If you want to cite CLDB and HyperCLDB, please use the following reference:

P. Romano, A. Manniello, O. Aresu, M. Armento, M. Cesaro, B. Parodi.
Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines.
Nucleic Acids Research 2009 37(Database issue):D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105