BITS Meetings' Virtual Library:
Abstracts from Italian Bioinformatics Meetings from 1999 to 2013


766 abstracts overall from 11 distinct proceedings





Display Abstracts | Brief :: Order by Meeting | First Author Name
1. Arisi I, Rosato V, Cattaneo A
Direct and reverse simulations of signal transduction pathways in PC12 cell
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

2. Bartocci E, Moeller S, Toldo L, Merelli E
Integration of EnsEMBL with BioAgent
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

3. Bersani E, Aluffi-Pentini F, De Fonzo V, Parisi V
La cellula virtuale: dalla genomica alla proteomica. Reti metaboliche e reti proteiche.
Meeting: BIOCOMP 2000 - Year: 2000
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Topic: Others

Abstract: Il Progetto Genoma, finalizzato al sequenziamento dell'intero genoma umano, sta fornendo delle utili indicazioni sulla struttura e la regolazione del DNA umano e permettera' la completa mappatura di tutti i geni e la loro distribuzione sui singoli cromosomi. Per comprendere tuttavia la funzionalita' del genoma, sara' necessario individuare le proteine codificate e comprendere le loro reti di interazioni nei vari compartimenti cellulari per completare la comprensione del ciclo vitale della cellula e poterne capire a fondo i malfunzionamenti legati a disfunzioni metaboliche e ai tumori. Le reti piu' semplici da studiare sono quelle metaboliche, mentre le reti di interazione tra enzimi sono molto piu' intricate. Il nostro gruppo ha cominciato uno studio finalizzato alla implementazione della cellula virtuale. Il primo passo di questo studio e' stata la simulazione di una cascata di chinasi/fosfatasi in interazione (BIOCOMP1999), limitandosi a problemi adimensionali, ossia trascurando lo spazio (trasporto e diffusione). Queste cascate di chinasi/fosfatasi fanno sì che specifici segnali provenienti da un recettore di membrana vengano trasdotti verso il nucleo. I risultati ottenuti con questa simulazione (in termini di variabili dinamiche che quantificano la concentrazione dei singoli enzimi considerati, inattivi o attivati) sono promettenti e stiamo estendendo i modelli per includere oltre alla rete metabolica, altre interazioni proteiche e la trasduzione del segnale all'interno del nucleo cellulare. In un prossimo futuro prenderemo in considerazione anche la struttura tridimensionale per studiare fenomeni quali quelli legati alle onde e alle oscillazione del calcio. La costruzione di questa "cellula virtuale", permettera' di studiare fenomeni, quali l'apoptosi e il ciclo cellulare, per cercare di comprendere l'insorgenza di malattie neurodegenerative e di tumori. Il modello esteso permette di includere i fattori di trascrizione che determinano l'espressione genica specifica del tipo cellulare e di capire come l'attivita' all'interno del nucleo influenzi la funzionalita' del genoma umano al di la' della sua semplice suddivisione in regioni codificanti e non codificanti.

4. Blasi MF, Bignami M, Giuliani A, Casorelli I
A new approach to identify genetic networks using microarrays data
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

5. Brannetti B, Helmer-Citterich M
Comparison of different tools for the prediction of protein interaction specificity
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

6. Bultrini E, Pizzi E, Del Giudice P, Frontali C
Extraction of a pentanucleotide vocabulary shared by introns and intergenic elements
Meeting: BIOCOMP 2002 - Year: 2002
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Topic: Others

Abstract: Missing

7. Bultrini E, Pizzi E, Del Giudice P, Frontali C
Symmetry properties of pentamer usage in non-coding DNA
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

8. Corà D, Provero P, Caselle M
Finding regulatory elements in eucaryotes: a statistical approach using Gene Ontology
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

9. Davassi A, Petrillo M, Paolella G
Sequence analysis with CAPRI, a web-desktop application
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

10. Emerson A, Liuni S, Castrignanò T, Rossi E
Plan for a National Infrastructure in Bioinformatics
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

11. Filippini F, Rossi V, Picco R, Floriduz M, Naccari T, Carpi A, Budillon A, Vacca M, Gianfrancesco F, Ciccodicola A, D'Urso M
From comparative genomics to ‘molecular bioinformatics’: an integrated approach to functional genomics
Meeting: BIOCOMP 2000 - Year: 2000
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Topic: Others

Abstract: Despite several genomes have been largely or completely sequenced, we are still far from a 'whole proteome' functional characterization. Thousands of 'hypothetical proteins', 'unique' (i.e. not homologous to any other) gene products, and even partially characterized proteins hide unknown, possibly important functions. In the absence of experimental confirmation, sequence analysis alone never demonstrates a function, and simple homology search is even unable to infer function from sequence for about a third of the gene products in any of the sequenced genomes. On the other hand, a 'brute-force' experimental characterization of whole proteomes would be too expensive and time-consuming. In order to find an alternative to shotgun characterization of gene products with unknown function, we are following a "molecular bioinformatics" approach, combining step-by-step in silico analyses with in vitro and in vivo prediction-driven experiments. This allowed to unravel molecular mechanisms underlying function of rolB plant oncogene (F. Filippini et al., Nature 379:499-500, 1996; V. Rossi et al., ms. in preparation) and of bifunctional phospholipase-chitinase EP3 (R. Picco et al., ms. in preparation); further, work is in progress about characterization of the unique N-terminal domain of SYBL1 (M. D'Esposito et al., Nature Genetics, 227-230, 1996), the molecular significance of MeCP2 mutations in Rett syndrome patients, to attempt a genotype-phenotype correlation (Vacca et al et al. , ms. in preparation) and about comparative analysis of mammalian and plant adaptins and protein tyrosine kinases. Using comparative analysis of mammalian and plant genomes we are searching for evolutionarily conserved "sequence function tags" - such as motifs and even weak homology regions - in order to get suggestions for a 'targetted' experimental approach to the demonstration of function or for the identification of homologous elements. This approach is finally aimed to unravel possibly the deregulation of important functions underlying a genetic diseases or fundamental genes involved in plant and mammalian developmental control.

12. Lanzarato F, Iazzetti G, Caserta E, Botta M, Franceschinis G, Calogero RA
RRE & ClAW: two new java tools for microarray data mining
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

13. Papaleo E, Santarossa G, Vai M, Fantucci P, De Gioia L
Structural model for Gas1p family members by combined threading and secondary structure prediction methods
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

14. Pugliese L
Annotation of EST sequences by a structural bioinformatics approach
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing

15. Temussi PA
The Mechanism of Interaction of Sweet Proteins with their Receptor: Modelling the Complexes
Meeting: BIOCOMP 2003 - Year: 2003
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Topic: Others

Abstract: Missing



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