Description
(TP53_MUTATION_FUNCTION1) |
Functional property of the mutant protein which is similar to the activity of the wild-type protein.
DNAb = DNA binding tested by gel-shift;
APO= induction of apoptosis when the mutant protein is overexpressed in human cells by transfection;
TA= trans-activation of a reporter gene under the control of a p53-responsive element (indicated in brakets);
GS= growth suppression (measured by colony forming assay) by the mutant protein when overexpressed
in human cells by transfection;
GA= growth arrest (measured by FACS) by the mutant protein when overexpressed in human cells by transfection;
TUMOR= transfection of mutant protein in human cells confer tumorigenicity in nude mice;
partial= the observed effect is partial
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