1. Gallimbeni R, Di Marino D, D'Annessa I, Morozzo della Rocca B, Desideri A, Falconi M
Membranome: an active web site
Meeting: BITS 2005 - Year: 2005
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Abstract: Membrane proteins play key role in cell biology e.g. as ion channels, drug receptors, and solute transporters. It has been estimated that ~25% of genes code for membrane proteins, and that ca. 50% of potential new drug targets are membrane proteins. Despite the central importance of membrane proteins, the number of high resolution structures (from X-ray diffraction and more recently from NMR) remains small but the literature about experimental data available is huge. Literature gives a large amount of disjointed information about this essential group of proteins that needs to be organized to give a direct access to the researcher. In order to ease the browse of experimental data we are preparing the “membranome” site. Membranome site will select, store and efficiently organize literature data about: - classification; - genomic and protein sequences; - expression, purification, crystallization and structure determination; - structure and function; - transmembrane regions predictions (if the structure is not available); - interactions between membrane proteins and the rest of cell components: ions, lipids, sugars, ligands, substrates, solvent, a variety of molecules and other proteins; - mutants, mutation technique, altered functionality and pathological consequences of mutations; - publication references.