1. Ferraro E, Via A, Ausiello G, Helmer-Citterich M
A new neural network approach for the inference of SH3 domains specificity
Meeting: BITS 2005 - Year: 2005
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Abstract: SH3 domains bind polyproline II peptides characterized by the PxxP consensus (P is proline and x in any amino acid). Single domain specificities display a preference for peptides within a range of variability on the common structural theme and different domains may interact with common peptides. We defined a new neural strategy to extract information from interacting partner sequences to improve the identification of SH3 domains specificity.