1. D'Ursi P, Salvi E, Fossa P, Milanesi L, Rovida E
Modelling the interaction of steroid receptors with organic polychlorinated compounds
Meeting: BITS 2005 - Year: 2005
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Abstract: The organic polychlorinated compounds like dichlorodiphenyltrichloroethane (DDT) with its metabolites and polychlorinated biphenyls (PCBs) are present in atmospheric particulate as persistent contaminants. They have been recognized to have detrimental health effects both on wildlife and humans acting as endocrine disrupters (EDC) due to their ability of mimicking the action of the steroid hormone thus interfering with hormone response. There are several experimental evidences that they bind and activate human steroid receptors. Despite the growing concern about the toxicological activity of EDC, molecular data of the interaction of this compounds with biological targets are still lacking. In order to better understand the ability of EDC to bind in the receptor hormone binding pocket, we have simulated by docking approach the molecular models of the complexes of estrogen, progesterone and androgen receptors with DDT and PCB family compounds.