Abstract: Within the Biosapiens network of excellence (EC Framework VI), the Biocomputing Group of the Bologna University installed a DAS server in a pipeline connected to the EBI. Our task in collaboration with Gunnar von Hejne (Stockholm Bioinformatics Center, SCFAB, Stockholm University, Sweden), Gert Vriend (CMBI University of Nijmegen, the Netherlands) and David Jones (Bioinformatics Unit, University College London, United Kingdom) is the large scale screening of the human genome in order to annotate membrane proteins based on topology prediction of chains.