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1. Pasa S, Kohn KW, Aladjem MI, Consiglieri C, Cocozza S, Bordo D, Parodi S In silico model of Molecular Interaction Maps: c-Myc and cell cycle control Meeting: BITS 2004 - Year: 2004 Full text in a new tab Topic: Unspecified Abstract: Cell behaviour is largely determined by protein:protein interactions. In particular, it has become increasingly evident that cell cycle control, differentiation and death are governed by networks of molecular interactions involving both proteins and DNA. The concomitant rapid increase of data concerning gene expression as measured in large scale experiments, has made evident the need to represent biochemical effectors (proteins and DNA) and their mutual interaction in an integrated way, in the form of a Molecular Interaction Map (MIM). To describe MIMs in a coherent graphical notation, the use of “wiring diagrams” similar to those adopted in electronics is proposed. In this work we describe the main features of a MIM focused on the oncogene c-Myc and on its role in cell cycle control. |