BITS Meetings' Virtual Library:
Abstracts from Italian Bioinformatics Meetings from 1999 to 2013

766 abstracts overall from 11 distinct proceedings

1. Barberis M, De Gioia L, Ruzzene M, Sarno S, Coccetti P, Pinna LA, Vanoni M, Alberghina L
The Cyclin-Dependent Kinase Inhibitor Sic1 of Saccharomyces cerevisiae Is a Functional and Structural Homologous to the Mammalian p27Kip1
Meeting: BITS 2004 - Year: 2004
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Topic: Unspecified

Abstract: In budding yeast Sic1, an inhibitor of cyclin-dependent kinase (Cki), blocks the activity of Cdk1-Clb5/6 (S-Cdk1) kinase required for the initiation of DNA replication that takes place only when Sic1 is removed . Deletion of Sic1 causes premature DNA replication from fewer origins, extension of the S-phase and inefficient separation of sister chromatids during anaphase, whereas delaying S-Cdk1 activation rescues both S and M phase defects. Despite the well documented relevance of Sic1 inhibition on S-Cdk1 for cell cycle control and genome instability, the mechanism by which Sic1 inhibits S-Cdk1 activity remains obscure. Sic1 has been proposed to be a functional homologous of mammalian Cki p21Cip1, that is characterized by a significant sequence similarity with Cki p27Kip1, inhibitor of the Cdk2/Cyclin A kinase activity during S-phase.

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