1. Passamano M, D'Agostino N, Caprera A, Milanesi L
Comprehensive Analysis of Protein Kinase Domains
Meeting: BITS 2004 - Year: 2004
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Topic: Structural genomics
Abstract: Eukaryotic protein kinase (ePKs) constitute one of the largest recognized protein families represented in the human genome and are important players in virtually every signaling pathway involved in normal development and disease. The key feature that distinguishes ePKs superfamily members from other proteins is the sequence of contiguous stretch of approximately 250 aminoacids that constitutes the catalytic domain [1-2] . Around half the human kinases contain other domains in addition to the catalytic domain, which often are involved in kinases regulation, interactions with other partners or subcellular localization . Domains present one of the most useful levels at which to understand protein function and domain family-based analysis, so we developed an automated analysis system for studying domain statistic distribution of kinase superfamily.