Abstract: The CODE project aims to provide a comparative genomics analysis of curated disease genes families. It integrates experimental and human verified information into automated gene-centric pipelines, which regularly map disease genes and related features across available sequenced metazoan genomes. Of particular interest to the outcome of the project is the semi-automated annotation of non-coding sequences (ncRNA, promoters, enhancers and splice regulators). Considerable attention is paid to the evolutionary clues provided by the analysis in particular when model animals are concerned. Finally, the establishment of a community portal, complementary to the existent international projects, will disseminate the results of the research and augment the annotation of disease genes.