This is the Germline Mutations data set of the IARC TP53 Mutation Database (Rel. 12)
The dataset of germline mutations is a module of the IARC TP53 Database.
It contains information on families fulfilling the definition of Li-Fraumeni
and Li-Fraumeni-related syndromes and on individuals carrying a germline mutation
in the TP53 gene. Data are extracted from peer-reviewed articles.
Unpublished data from Eeles et al are also included.
Criteria for inclusion are the following: a) individuals carrying a sequenced
TP53 germline mutation, affected or not by a cancer, b) individuals affected
by a cancer and belonging to a family defined as LFS or LFL, presenting or
not a germline mutation (TP53 or other).
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