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TISSUE/ORGAN: thyroid, medullary
ECACC catalog code: 92013101
Morphology: Spherical, cells grow in large clusters
Description: Human medullary thyroid carcinoma
Viruses: See Properties
Depositor: Dr R Pfragner, Karl-Franzens University, Graz, AUSTRIA (Originator)
Restricted. Patent: None Specified By Depositor
Properties: Products: Peptides eg calcitonin, calcitonin-gene related peptide, gastric-releasing peptide, somatostatin Applications: Neuroendocrinology, cytogenetics, MEN2-syndrome
Available in the following LABORATORY:
Part of the Business Division of the Health Protection Agency (ECACC, Salisbury, Wiltshire)
Ham's F12 + 2mM Glutamine + 10% Fetal Bovine Serum (FBS). Maintain cultures between 3-5x100,000 cells/ml; 5% CO2; 37C.
Originated from C-cells of the thyroid gland known to produce several peptides including serotonin. The loose attachment of the cells corresponds to the lack of cellular junctions.
Research council deposit: No;
Price Code: C;
Validated by: isoenzymes (species confirmation)
- Cancer Res 1990;50:4160-4166 - PMID: 1972348
For information, get in touch with:
IRCCS Ospedale Policlinico San Martino
Largo Rosanna Benzi, 10 - I-16132 Genova - Italy
Dott.ssa Barbara Parodi
If you want to cite CLDB and HyperCLDB, please use the following reference:
P. Romano, A. Manniello, O. Aresu, M. Armento, M. Cesaro, B. Parodi.
Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines.
Nucleic Acids Research 2009 37(Database issue):D925-D932.