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For information, get in touch with: Dott.ssa Barbara Parodi
Email: barbara.parodi@hsanmartino.it
  P. Romano, A. Manniello et al. Nucl Acids Res 2009 37:D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105


U-937 (human, Caucasian, pleural effusion, lymphoma, histiocytic)

Monoclonal continuous culture, grown as suspension
histomonocytoid morphology
SPECIES: human, Caucasian (male, 37 years old)
TISSUE/ORGAN: pleural effusion
TUMOR: lymphoma, histiocytic
Susceptibility to viruses: HIV-1 * HIV-2
PROPERTIES: IL-1 prod.; specialized product secr.; tumor markers; Fc receptor; monocytic differentiation; differentiation; antitumour testing; cell biology; virology; tumorigenicity; c-myc mRNA expression; C3b receptor

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: CRL 1593, DSMZ: ACC 5, ICLC: HTL94002

Bibliographic references:


U-937 (human, lymphoma, histiocytic)


SPECIES: human
TUMOR: lymphoma, histiocytic

DSMZ catalog code: ACC 5
Morphology: round to polygonal, single cells in suspension
Susceptibility to viruses: HIV-1 * HIV-2
Description: human histiocytic lymphoma established from the pleural effusion of a 37-year-old man with generalized diffuse histiocytic lymphoma in 1974; cells were described to express markers and properties of monocytes; patented cell line; cells express mRNA for c-myc confirmed as human with IEF of AST, MDH, NP
Viruses: ELISA: reverse transcriptase negative; PCR: EBV-, HBV-, HCV-, HHV-8-, HIV-, HTLV-I/II-
Depositor: Dr. K. Nilsson, University Hospital, Uppsala, Sweden
General Restrictions

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: CRL 1593, ICLC: HTL94002

Bibliographic references:


U-937 (human, Caucasian, pleural effusion, lymphoma, histiocytic)

ICLC catalog code: HTL94002
Continuous culture, grown as suspension
histomonocytoid morphology
SPECIES: human, Caucasian (male, 37 years old)
TISSUE/ORGAN: pleural effusion
TUMOR: lymphoma, histiocytic
Susceptibility to viruses: HIV-1 * HIV-2
DEPOSITOR: Obtained from ATCC. Established by C. Sundrom and K. Nilsson in 1974.
Cell line available for distribution. The cell line must not be exploited commercially
PROPERTIES: IL-1 production; specialized product secretion; tumor markers; Fc receptors; antitumour testing; virology; tumorigenicity; expression of markers and properties of monocytes, expression of mRNA for c-myc.

Available in the following LABORATORY:

Availability in cell line catalogues: DSMZ: ACC 5

Bibliographic references:


U-937 (human, Caucasian, pleural effusion, lymphoma, histiocytic)

Continuous culture, grown as suspension
histomonocytoid morphology
SPECIES: human, Caucasian (male, 37 years old)
TISSUE/ORGAN: pleural effusion
TUMOR: lymphoma, histiocytic
Susceptibility to viruses: HIV-1 * HIV-2
PROPERTIES: IL-1 prod.; specialized product secr.; tumor markers; Fc receptor; monocytic differentiation; differentiation; antitumour testing; cell biology; virology; tumorigenicity; c-myc mRNA expression; C3b receptor

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: CRL 1593, DSMZ: ACC 5, ICLC: HTL94002

Bibliographic references:


U-937 (human, Caucasian, pleural effusion, lymphoma, histiocytic)

Continuous culture, grown as suspension
histomonocytoid morphology
SPECIES: human, Caucasian (male, 37 years old)
TISSUE/ORGAN: pleural effusion
TUMOR: lymphoma, histiocytic
Susceptibility to viruses: HIV-1 * HIV-2
PROPERTIES: IL-1 prod.; specialized product secr.; tumor markers; Fc receptor; monocytic differentiation; differentiation; antitumour testing; cell biology; virology; tumorigenicity; c-myc mRNA expression; C3b receptor

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: CRL 1593, DSMZ: ACC 5, ICLC: HTL94002

Bibliographic references:


U-937 (human, Caucasian, pleural effusion, lymphoma, histiocytic)

Monoclonal continuous culture, grown as suspension
histomonocytoid morphology
SPECIES: human, Caucasian (male, 37 years old)
TISSUE/ORGAN: pleural effusion
TUMOR: lymphoma, histiocytic
Susceptibility to viruses: HIV-1 * HIV-2
PROPERTIES: IL-1 prod.; specialized product secr.; tumor markers; Fc receptor; monocytic differentiation; differentiation; antitumour testing; cell biology; virology; tumorigenicity; c-myc mRNA expression; C3b receptor

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: CRL 1593, DSMZ: ACC 5, ICLC: HTL94002

Bibliographic references:


U-937 (human, Caucasian, pleural effusion, lymphoma, histiocytic)

Continuous culture, grown as suspension
histomonocytoid morphology
SPECIES: human, Caucasian (male, 37 years old)
TISSUE/ORGAN: pleural effusion
TUMOR: lymphoma, histiocytic
Susceptibility to viruses: HIV-1 * HIV-2
PROPERTIES: IL-1 prod.; specialized product secr.; tumor markers; Fc receptor; monocytic differentiation; differentiation; antitumour testing; cell biology; virology; tumorigenicity; c-myc mRNA expression; C3b receptor

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: CRL 1593, DSMZ: ACC 5, ICLC: HTL94002

Bibliographic references:



For information, get in touch with:
IRCCS Ospedale Policlinico San Martino
Largo Rosanna Benzi, 10 - I-16132 Genova - Italy
Dott.ssa Barbara Parodi
Email: barbara.parodi@hsanmartino.it

If you want to cite CLDB and HyperCLDB, please use the following reference:

P. Romano, A. Manniello, O. Aresu, M. Armento, M. Cesaro, B. Parodi.
Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines.
Nucleic Acids Research 2009 37(Database issue):D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105