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For information, get in touch with: Dott.ssa Barbara Parodi
Email: barbara.parodi@hsanmartino.it
  P. Romano, A. Manniello et al. Nucl Acids Res 2009 37:D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105


SK-N-MC (human, Caucasian, neuroblastoma)

Monoclonal continuous culture, grown as monolayer
neuroblast-like morphology
SPECIES: human, Caucasian (female, 14 years old)
TUMOR: neuroblastoma
tumorigenic in nude mice
PROPERTIES: biochemical markers; catecholamine prod.; receptor; chemotherapeutic agents; neural tissue

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: HTB 10, ECACC: 90022302, DSMZ: ACC 203

Bibliographic references:


SK-N-MC (human, Caucasian, neuroblastoma)


SPECIES: human, Caucasian
TUMOR: neuroblastoma

DSMZ catalog code: ACC 203
Morphology: adherent, fibroblast-like cells growing as monolayers
Description: human neuroblastoma established from the supraorbital metastasis of a neuroblastoma of a 14-year-old girl in 1971 (see ATCC HTB 10); although described in the original paper as neuroblastoma, SK-N-MC is now widely regarded as having originated from the morphologically similar Askin's tumor related to Ewing's sarcoma; FLI1-EWS gene fusion, the molecular pathological change in Ewing's sarcoma and Askin's tumor, was shown in SK-N-MC by Dunn et al. (Cancer Genet. Cytogenet. 76: 19-22, 1994) confirmed as human with IEF of AST, MDH
Viruses: ELISA: reverse transcriptase negative; PCR: EBV-, HBV-, HCV-, HHV-8-, HIV-, HTLV-I/II-
Depositor: Dr. H. G. Drexler, DSMZ, Braunschweig, Germany
General Restrictions

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: HTB 10, ECACC: 90022302

Bibliographic references:


SK-N-MC (human, Caucasian, neuroblastoma)

Continuous culture, grown as monolayer
neuroblast-like morphology
SPECIES: human, Caucasian (female, 14 years old)
TUMOR: neuroblastoma
tumorigenic in nude mice
PROPERTIES: biochemical markers; catecholamine prod.; receptor; chemotherapeutic agents; neural tissue

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: HTB 10, ECACC: 90022302, DSMZ: ACC 203

Bibliographic references:


SK-N-MC (human, Caucasian, neuroblastoma)

Monoclonal continuous culture, grown as monolayer
neuroblast-like morphology
SPECIES: human, Caucasian (female, 14 years old)
TUMOR: neuroblastoma
tumorigenic in nude mice
PROPERTIES: biochemical markers; catecholamine prod.; receptor; chemotherapeutic agents; neural tissue

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: HTB 10, ECACC: 90022302, DSMZ: ACC 203

Bibliographic references:


SK-N-MC (human, Caucasian, neuroblastoma)

Continuous culture, grown as monolayer
neuroblast-like morphology
SPECIES: human, Caucasian (female, 14 years old)
TUMOR: neuroblastoma
tumorigenic in nude mice
PROPERTIES: biochemical markers; catecholamine prod.; receptor; chemotherapeutic agents; neural tissue

Available in the following LABORATORY:

Availability in cell line catalogues: ATCC: HTB 10, ECACC: 90022302, DSMZ: ACC 203

Bibliographic references:



For information, get in touch with:
IRCCS Ospedale Policlinico San Martino
Largo Rosanna Benzi, 10 - I-16132 Genova - Italy
Dott.ssa Barbara Parodi
Email: barbara.parodi@hsanmartino.it

If you want to cite CLDB and HyperCLDB, please use the following reference:

P. Romano, A. Manniello, O. Aresu, M. Armento, M. Cesaro, B. Parodi.
Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines.
Nucleic Acids Research 2009 37(Database issue):D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105