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For information, get in touch with: Dott.ssa Assunta Manniello
Email: mariaassunta.manniello@hsanmartino.it
  P. Romano, A. Manniello et al. Nucl Acids Res 2009 37:D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105

Fibroblast collection from patients affected with familial hypercholesterolemia and other metabolic disorders


Skin fibroblasts from a series of patients affected by Familial Hypercholesterolemia (FH) have been collected in the last few years. The following assays are routinely performed on these cells: a) LDL-receptor function; b) Northern blot; analysis of synthesis and intracellular processing of LDL-receptor proteins. From each FH cell line, DNA is also available. Furthermore, dermal fibroblasts from a series of connective disorders, both heritable and acquired, have been collected, from biopsies of the forearm skin or from the affected areas. In all cases, samples were examined by optical and electron microscopy.

Roberta Tiozzo
Laboratorio di Colture Cellulari
Istituto Patologia Generale, Universita' degli Studi
Via Campi, 287
41100 Modena Italy
Phone: +39-0592055422-2055427 Fax: +39-0592055426
E-mail: tiozzorb@unimo.it



For information, get in touch with:
IRCCS AOU San Martino IST,
c/o Centro Biotecnologie Avanzate, Torre D - Piano 2

Largo Rosanna Benzi, 10 - I-16132 Genova - Italy
Dott.ssa Assunta Manniello
Email: mariaassunta.manniello@hsanmartino.it

If you want to cite CLDB and HyperCLDB, please use the following reference:

P. Romano, A. Manniello, O. Aresu, M. Armento, M. Cesaro, B. Parodi.
Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines.
Nucleic Acids Research 2009 37(Database issue):D925-D932.
DOI: doi:10.1093/nar/gkn730; PMID: 18927105