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SPECIES: human, Caucasian
TUMOR: carcinoma, small cell
ECACC catalog code: 95062825
Morphology: Floating aggregates
Description: Human Caucasian lung small cell carcinoma, metastasis to bone marrow
Viruses: See Properties
Depositor: Prof OS Pettengill and Dr G D Sorenson, Dartmouth Medical School, Lebanon, NH, USA (Originator)
No restrictions. Patent: None Specified By Depositor
Properties: Applications: Human lung tumour model
Available in the following LABORATORY:
Part of the Business Division of the Health Protection Agency (ECACC, Salisbury, Wiltshire)
Waymouth's MB 752/1 + 2mM Glutamine + 10% Fetal Bovine Serum (FBS) (Heat Inactivated). Maintain cultures between 3-9x100,000 cells/ml; 5% CO2; 37C.
Karyotype: Modal No 44
DMS 92 was obtained from a bone marrow aspirate of an untreated 39 year-old male at time of diagnosis. The isolated cells were identified as small cell carcinoma of the lung (SCLC). DMS 92 cells secrete adrenocorticotropin (ACTH), bombesin (BN), oxytocin-neurophysin (OT-NP) and 17 beta-estradiol. Cells produce tumours in athymic nude mice.
Research council deposit: No;
Price Code: C;
Validated by: isoenzymes (species confirmation)
- Cancer 1980;45:906 - PMID: 7397666
- Cancer 1981;47:1289 - PMID: 6261922
- Exper Cell Biol 1980;48:279
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Dott.ssa Barbara Parodi
If you want to cite CLDB and HyperCLDB, please use the following reference:
P. Romano, A. Manniello, O. Aresu, M. Armento, M. Cesaro, B. Parodi.
Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines.
Nucleic Acids Research 2009 37(Database issue):D925-D932.